The purpose of this study was to evaluate and evaluate the use of managers' information security management systems in agility and decision making process.This research is applied in terms of purpose and descriptive-survey method.The statistical population of the study was the managers and experts of the Administrative,Financial and Resource Management Organization of the Ministry of Science of Tehran, which was selected by cluster sampling method and then the required research information was collected from all senior and middle managers of those organizations.In total, the statistical sample size was 205 people.A questionnaire was used to collect data and descriptive statistics(frequency distribution table, frequency percentage)and inferential statistics(Kolmogorov-Smirnov test, t-test, Spearman correlation coefficient test, stepwise multiple regression test)were used to analyze the data Is The results showed that there is no significant difference between the two groups of male and female managers in the use of management information security system.Also, no difference was observed between groups with different levels of organizational status in its use.There is also a difference between managers' use of information security system based on age groups, so that older managers use this system less and there is a difference between the use of this system based on service groups.Stepwise regression analysis indicates that the six factors of manager awareness, organizational support, financial support, Internet use, manager support, availability and belief in effectiveness as the most important factors influencing the use of information security system can be a reliable model for Provide an estimate of the use of this system.